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Central neurocytoma : ウィキペディア英語版 | Central neurocytoma
Central neurocytoma, abbreviated CNC, is a rare, ordinarily benign intraventricular brain tumour that typically forms from the neuronal cells the septum pellucidum. The majority of central neurocytomas grow inwards into the ventricular system forming interventricular neurocytomas. This leads to two primary symptoms of CNCs, blurred vision and increased intracranial pressure. Treatment for a central neurocytoma typically involves surgical removal, with an approximate 1 in 5 chance of recurrence.〔 Central neurocytomas are classified as a grade II tumor under the World Health Organization's classification of tumors of the nervous system. ==History== It was first described in 1982 by Hassoun. Central neurocytomas are rare brain tumors that are located most of the times in the lateral ventricles near the Monro foramina. They were first discovered by Hassoun and co-workers in 1982, and were classified as grade II tumors. In 1985, Wilson had also described a rare case of "differentiated neuroblastoma" in the lateral ventricle that resembles oligondendroglioma on light microscopy. However, the name central neurocytoma was given by Hassoun. Primary neuronal tumors occurring in the ventricular system were considered to be rare. Most cases described were of non-neuronal origin such as oligodendroglioma, ependymoma, meningioma, choroid plexus papilloma and giant cell. Neurocytomas were probably historically misdiagnosed as intraventricular oligondedronglioma or clear cell ependymoma prior to this. With its non-aggressive behavior the tumor has often been called "benign central neurocytoma". It is believed to occur in young adults from the neuronal cells of the septum pullicidum and the subependymal cells of the lateral ventricles. Most of the initial incidents reported in the lateral ventricle were benign. However, as more information was gathered the name benign central neurocytoma was started to be seen as a double misnomer because these tumors are not always benign nor centrally located. Many recent studies suggest that their location, biological potential and clinical behavior are observed be more variable than previously thought. Recent studies indicate their uncommon location, aggressive biological behavior and frequent recurrences following after surgical resection have generated significant interest in various treatment modalities and also in their terminology, lineage potential and molecular regulation.〔
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